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TimesET Times New Roman " 1 h ,fc2c2; B | : , : . ICCIDD xxxAlexandre Katalov (ICCIDD). Micronutrient Initiative (, ), E. Merck (, ) SQM Iodine (, ), .
John B. Stanbury
Francois Delange
John T. Dunn
:
J.B.Stanbury1, A.E.Ermans2, P.Bourdoux3, C.Todd4, E.Oken5, R.Tonglet6, G.Vidor7, L.E.Braverman8, G.Medeiros-Neto9
(), , , , , . (). , , , . , . - , , . , -, , . , , . . , ( ) - . , . , , .
___________
1 , , . 2 , . 3 , .
4 , , . 5 , , , .
6 , , . 7 , , , , .
8 , , .
9 , .
, , , , 1996.
, (Dunn JT, Semigran MJ, Delange F. orvilain B., Van Sande J., Dumont JE, et al.), (), , , 3 4 1996 . , Ermans . (1) , (2). Bourdoux . (3) 1995 . 2- , , , . , Emily Oken ( Oken), c, (4). - John Stewart - George Vidor , , , 20 . , , - .
- Ermans Bourdoux 1995 . , . , , (5). (6). , . - , , , - .
Coindet (7,8) , , Gairdner (9). Coindet , , , . , , Parry (10), 1825 . , , .
19 , (11,12). . Breuer 1900 . (12), 1910 . Kocher (13), -. , von Basedow Graves , , . , 1917 . Marine Kimball , , (14). Plummer (15) , : , , ( . Webster Chesney (16,17), , .
(18,19), (20-22 ). . , .. , . , (23,24). , Plummer (15), , , . , , , , .
Breuer (12) Kocher (13) , . Wolff (25), Fradkin Wolff (26), Braverman (27), Laroche Hirsch (28), Kobberling Hintze (29), Hetzel (30) Pennington (31); , Hall Kobberling (32), Journal of Molecular Medicine 1980 . (33), (34,35), , Braverman Utiger 1991 . (36). Delange (37), , . , , , , , . , , (38), (39). , (37).
, 1941 1945 (40,41) (42) , (43).
1924 1928 . Kohn (44,45). , , , , . , , . , 1926 . .
3 100000 1923 . 10 100000 1927 . 1930 . (46). McClure (47,48), , , , , . , , , . .
1909 . Marine Lenhart (49), , . 0,2 10 (50-54). , , , . , 100 . 1925 . Kimball (55) , , , , , .
1925 . A.S.Jackson 18 , , -, , 50, 3 (56-58). ( ); . Jackson , . , . . , , -. Jackson , 1934 . Goetsch (59), , , , .
Hartsock (60,61) , , . 0,02% 0,01%. , 10 , 1 . Hartsock , 1-18 , - , ,. , . 6 Hartsock 50 . , . , , : ( 40-40 , , , , , , , 2/3 . , . , 77 - , , , , , (62). Lahey, , (63).
, , , . , ( ) , , . Jackson , , . , McClure , Kohn (45), , , , .
1930 . , - . . . . , - . , , 1950- 1960- (63) .
1960- (64-77). , , . . Clements 1948 . (74), . 1950 . , c 10 KI. , 1960- . ( 2 ) , . 1960- . , 80-270 , , 173 264 (75). , , . , , . , , . , 1976 . , .
, 1964-1965 ., , , . 6 - - . 24 100000 1963 . 40 1964 1965 1967 ., 125 , 370000 . , , 1971, 1977-1978 1980 , (.1). , - Vidor - Stewart , , , . . , , . , , , , , , ( ) . . 1983 . . (3) , 10% 3-, .
, (76). , (77). . , , . . , , , .
. , , , 1966 1987 49 . 44 , , , 21 . , , . , , .
, , , , , . , ( Ingbar /78/).
, - , , -, . 0,1 0,25 (480 /) . ( 1 840 , 25% 50 ), , 191 60 ( ) : 1,6 /100 24 /100 . , 14 15 - 3 (4) (1). 1 (3), , , . , , , , -, ; , (3,79).
(80-83). 1966 . . , , , , . 299 (81), 33 4, 2 (4), . 1,0 / . , , 1990 ., ; , 10 20 (82). 1992 . . (82), (83).
1995 . , , 30 90 1 ( , ). , , , , , 10 : 2 /100 1983 . 28,3 /100 1994 .
1994 . . . (4) , , . ( ), 1992 . . 14 , . , , , . 1991 1995 . 1995 . 40 60 , . 91% . . , , . , , .
, , , .
(84,85). Mach (86). Marine Kimball, 10- , 1923 . 3,75 (87). , . 20 55-60 (88). , 300000 , , 5. 1980 . 15 , 90 150 / . 2 10%, . , , , (Burgi, ). , , (89).
, , 1978 1990 ( 109000 ) 27%- 15 ; (90). , .
Burgi (Burgi, ), , . 60 / 35 /, 7,5 . , , , 8 . , , , , .
, 1984 1989 . 3-8 , 150-200 . . . 5 , 10 . 6-10 .
Martins . (92), , 85%, 1876 1 , 480 . 103 . 1663 6 , 5 . 8 103 , , . 5 . 3. Maberly (93) , , .
4 . 46- , , 1500 . 33- - , 78- . . (94). 470 ( ), , 3 (95). - 14- . 4 . .
14 , , , 400 (96). 4-10 . 5 , 4 - 4 . 45 2,9 /, 4 4,0 15,3 /100 , 3 - 84 330 /100 . 3 , . 15 , - . 8 . , , , - .
900 , 6 , , . (97,98). 3 . 2-3 , , , ; .
1969 1971 ., 3 ( 100 ), . 1972 . 1978 ., . (99,100). , (101).
( 73000 ) . 4 . 120 160 (102).
Breuer (12). Riccabona (103). . 1903 ., (KI 5 ), . 1963 . 10 KI , , . 1990 . 20 , 3,3 100 1990 . 4,7 1992 ., . , 10 (104), (105).
, , 270 75% (93). 0,2 2 ( ) 50 1 10 2 . 21 105 . 1 45 . 2 5 52 , (1,6 /). 2 , . 1 3 , . 1 2 8 (6 2 ) , , , , . 4 , , . , -, , .
- , , , , . 4 , 1977 ., (48 I/ NaCl). 4 . 250000 (106).
Kusic , 4 ; 3 , . Kusic (107). Elnager 4 (3 - ), 117 (108). , , , , . .
:
, , , , (109-112) (108). , (113), (25 ), , (114). , , , (115). , , . , , .
, , (23,115-118), (118-123). 2 2 2-5 (119). 4 , , 250 KI (124). , (120). (125,126). , (127-130). , (131,132). 1960, 1975 1976 (28,133,134). Savoi . (134) 23 . - . - (135).
- . KI (136,137), - (, Purdue Frederick, Norwich, CT), (138,139), (140) - (141). - (142).
. , 100 400 2 4 16 (143), , 3 14 , 0,5 (144). , (145,146).
- ( )
; (147).
, (148-156). (157,158), - (159), (160-162), ( /163,164/), , - (164-170).
, , (171,172). Ek . (173) - , (10 2 ). () , 5 KI (23,24).
- (174), (175,176).
- , . (177-190) (191,192), (193-195), (196), (197,198), (199,200) . , (199).
, 37% (75 200- ). , -, in vivo. per os ; , 30 100 . 4 3 . , (201-207). , - . ( ), . , .
. , , (208-218). Leger . (148) 50% . Mechlis (215) , 6% , , , 2 12%, - , (219). , -, , . ,
braas
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shell omala
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5004.13 ()
775
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sharp ar-m205
2113
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